![]() In total, 1,536 miRNAs were detected in all the samples, including 1,240 known miRNAs and 296 predicted miRNAs. Subsequently, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses were performed to determine the biological functions of differentially expressed miRNAs. Next‑generation sequencing was used to determine the miRNA expression profiles in these cell lines. Three fulvestrant‑resistant breast cancer cell lines, namely MCF‑7‑CC, MCF‑7‑TT and MCF‑7‑21, were established using the human breast cancer cell line MCF‑7 as the parental cell line and fulvestrant as the screening drug in vitro. In the present study, the association between miRNA expression profiles and fulvestrant resistance was investigated in human breast cancer cell lines. MicroRNAs (miRNAs) are known to serve an important role in tumor chemoresistance. Fulvestrant resistance is a major clinical issue in the treatment of endocrine‑based breast cancer. ![]()
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